Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.

The Prader-Willi syndrome (PWS [MIM 17620]) and 5 Piece Full Poster Bedroom Angelman syndrome (AS [MIM 105830]) locus is controlled by a bipartite imprinting center (IC) consisting of the PWS-IC and the AS-IC.The most widely accepted model of IC function proposes that the PWS-IC activates gene expression from the paternal allele, while the AS-IC ac

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